INS and Insulin resistance: T1DM is characterized by the destruction of insulin-producing β-cell of the islets of the pancreas by an autoimmune reaction which leads to a complete deficiency of insulin.[2,4] On the other hand, hyperglycemia in T2DM arises from the inability of the body’s cells to respond fully to insulin, a condition termed insulin resistance.[5] With the onset of insulin resistance, the hormone is less effective and, in due course, prompts an increase in insulin production.