In this subtype, the tumor often undergoes diffuse leptomeningeal dissemination throughout the central nervous system, resulting in invasive growth along the spinal cord.[12] Additionally, C-MYC amplification has been significantly associated with metastatic medulloblastoma in children.[13–15] Moreover, C-MYC promotes the generation of mesenchymal cells with high migratory ability through targeting epithelial–mesenchymal transition (EMT). This evidence concerns the gene MYC and neoplasm.