Renal function is the term used to describe how well the kidneys are functioning and their capacity to remove waste from the blood.[15] Obesity and T2DM both increase the risk of renal problems, including diabetic nephropathy.[16] In order to shed light on the potential influence of leptin on kidney health in this population, this study examines whether serum leptin levels are related to renal function in people with T2DM and obesity. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.