In the tumor diameter group, 27 out of 48 cases (27/48, 56.3%) were positive for MACC1, and 38 out of 58 cases (38/58, 65.5%) were positive for MACC1 in the ≥ 4.0 cm group (P = .329); in the group with and without smoking history, MACC1 expression was positive in 47 of 81 (47/81, 58.0%) cases in the nonsmoking group and in 18 of 25 (18/25, 72.0%) cases in the smoking history group, and there was no significant difference in the smoking history group (χ2 = 2.772, P = .100). The gene discussed is MACC1; the disease is neoplasm.