This gene plays a critical role in modulating the structure of the cell membrane through its interactions with integrins and other proteins belonging to the transmembrane 4 superfamily.[7] Furthermore, KAI1 has been shown to impede the process of epithelial–mesenchymal transition (EMT) in cancer cells, thereby contributing to its biological functions.[8] It also influences the Wnt/β-catenin signaling pathway, which serves to enhance cellular adhesion, stabilize the E-Cadherin/β-catenin complex, and prevent the detachment of cancer cells from the primary tumor site. The gene discussed is CDH1; the disease is neoplasm.