As a protein disulfide isomerase, AGR2 is instrumental in the folding and maturation of receptor proteins.[16] Furthermore, AGR2 functions as an oncogenic protein found in numerous cancers, where it modulates p53-related signaling pathways and promotes the expression of EGFR ligand proteins, thereby enhancing cell survival and stimulating the growth of cancer cells.[17] AGR2 is often overexpressed in various malignancies, including breast, oral, lung, prostate, and pancreatic cancers, and serves as a reliable biomarker for prognosis in clinical settings.[18]. This evidence concerns the gene P4HB and cancer.