Lymph node metastasis, which reflects the tumor’s biological behavior, demonstrated KAI1 positivity in 38 of 68 cases (55.9%) in the N0 group, whereas only 5 of 38 cases (13.2%) in the N1 group were positive, indicating a statistically significant difference in KAI1 expression related to lymph node status (χ2 = 18.191, P < .001). The gene discussed is CD82; the disease is neoplasm.