MACC1 and neoplasm: Prior research has indicated that KAI1 can exert its biological effects by forming a complex with C-MET or by inhibiting HGF activation.[34] Specifically, KAI1 can suppress MACC1 activation, thereby hindering the migration and metastasis of tumor cells.[35] Furthermore, KAI1 expression was also found to be inversely related to AGR2 expression.