Among 32 patients with stage I tumors, 3 cases were positive (3/32, 9.4%), in 35 cases of tumor stage II, 14 cases were positive (14/35, 40.0%), and in 36 cases of tumor stage III, 19 cases were positive (19/36), the expression of AGR2 was positive in 3 cases of stage IV, and there was a significant difference in the expression of AGR2 among the groups of TNM stage (χ2 = 19. Here, AGR2 is linked to neoplasm.