Notably, KAI1 has been found to counteract the stimulatory effect of β-catenin’s tyrosine phosphorylation on hepatocyte growth factor (HGF).[9] A growing body of evidence indicates that the down-regulation or complete loss of KAI1 expression is a significant factor promoting tumor metastasis and is closely linked to unfavorable prognoses across various forms of human malignancies.[10]. The gene discussed is HGF; the disease is neoplasm.