In a multivariate regression model adjusted for age, diabetes mellitus, LVEF, NT‐proBNP levels, and absolute peak VO2 values, CT values of miR‐22 (adjusted OR 0.409, 95% CI 0.193–0.867, p = 0.020) and BMI (adjusted OR 0.784, 95% CI 0.642–0.958, p = 0.018) were still significantly associated with secondary sarcopenia in HF patients. This evidence concerns the gene NPPB and hydrops fetalis.