Estrogen's protective effects against cardiovascular disease (CVD) have been well‐documented (Iorga et al., 2017; Wake & Yoshiyama, 2009), particularly in premenopausal women, where it is believed to confer reduced CVD risk through mechanisms involving estrogen receptor signaling (Menazza & Murphy, 2016; Ueda et al., 2020). The gene discussed is ESR1; the disease is cardiovascular disorder.