Among these, six markers (AXIN-1, ST1A1, CXCL1, STAMBP, SIRT2, and CASP8) were increased only in IPAH, while 11 inflammatory markers were augmented in patients with SSc-PAH and IPAH: VEGFA, CD8A, CXCL9, MMP1, IL-15RA, PD-L1, HGF, TNF, X4EBP1, CCL28, and CD40 [95]. The gene discussed is TNF; the disease is pulmonary arterial hypertension.