Patients with BNP < 50 pg/mL or NT-proBNP < 300 pg/mL demonstrated significantly better outcomes, while those with BNP > 180 pg/mL or NT-proBNP > 1500 pg/mL had a higher risk of morbidity and mortality [38].These thresholds were further incorporated into the REVEAL 2.0 risk score, a widely used tool to predict 1-year survival in PAH. Here, NPPB is linked to pulmonary arterial hypertension.