Toll-like receptors (TLR) 1, TLR2, TLR4, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and CD163 mediate the interaction between macrophages and M. leprae in leprosy, which increases IL-6 and IL-10 secretion. The gene discussed is IL6; the disease is leprosy.