Among the many networks predicted for the TD group based on genes related to PVT lapses was one centered on Extracellular Signal-Related Kinases 1/2 (ERK1/2), and involved differentially expressed genes AKAP5, CXCR1, and LITAF as well as predicated activation of the Hypoxia Inducible Factor 1 (HIF1) complex containing members Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) and Hypoxia Inducible Factor 1 Subunit Alpha (HIF1A) (Fig. 5). This evidence concerns the gene AKAP5 and thanatophoric dysplasia.