Our results demonstrated that elevated levels of ARHGAP25 (IVW odds ratio [OR] = 1.45, p = 0.012), HLA‐DRB1 (OR = 2.24, p = 0.005), MERTK (OR = 1.10, p < 0.001), MS4A6A (OR = 1.15, p = 0.027), and SYK (OR = 1.13, p < 0.001) were associated with an increased risk of MS. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.