For example, the missense variant rs78534766 in ADCY7 and the FLT3 variant rs76428106 associated with large effects on hypothyroidism (OR = 1.4 and 1.37, respectively) but had a comparably small effect on TSH levels (s.d. = 0.04 and 0.08, respectively). Here, ADCY7 is linked to hypothyroidism.