In comparison, pLoF variants in NFATC1 (MAF < 0.001%—OR = 4.36, 95% CI = 2.11–8.99, P = 6.7 × 10−5) were associated with higher effect compared to TSHR pLoF variants, suggesting a potential monogenic role in hypothyroidism. The gene discussed is NFATC1; the disease is hypothyroidism.