TYK2 and autoimmune disease: We highlight two missense variants, rs149007883 in NFKBIZ (p.Gly102Ala; OR = 0.83) and rs34536443 (p.Pro1104Ala; OR = 0.87) in TYK2, and two intron variants rs13181561 (OR = 0.96) in STING1 and rs113473633 (OR = 0.90) in NKFB1. These variants were associated with lower levels of a panel of inflammatory mediators (Supplementary Fig. 2), including IFN-γ, CXCL10 and CXCL9, which make up key pathogenic pathways involved in autoimmune diseases related to hypothyroidism18,19.