Consistent with DSP analyses, we identified transcripts related to antimicrobial and immune responses, including PRRs, NF-κB and TRIM family members and interleukin signaling as well as transcripts involved in lipid metabolism, cellular stress and apoptosis/autophagy in both glioma and BrM (Fig. 5b and Supplementary Table 6). The gene discussed is TRAT1; the disease is central nervous system cancer.