Moreover, the mRNA levels of liver fibrosis-related factors, including transforming growth factor beta 1 (TGF-β1), collagen I (Col(1)), and Col(4), were reduced significantly in the Numb-OE group compared with the BDL and Numb-EV groups (P < 0.01) (Fig. 1l). This evidence concerns the gene NUMB and Hepatic fibrosis.