The result showed that Numb was widely expressed in the livers of healthy people, but its expression was clearly decreased in the livers of patients with AIH, HBV or PBC, as the Numb-positive staining area was reduced by 48%, 75% and 73%, respectively, compared with that in the healthy population (P <0.01) (Fig. 1a). The gene discussed is NUMB; the disease is autoimmune hepatitis.