TGFB1 and Hepatic fibrosis: Moreover, the mRNA levels of liver fibrosis-related factors, including TGF-β1, Col(1), and Col(4), were reduced significantly in the Numb-Exon3OE group compared with the Numb-Exon3EV group (P < 0.05 or P < 0.01) (Fig. 4j).