PGK1 and cholangiocarcinoma: Gao et al. reported that METTL3 upregulated the m6A modification of NFAT5, which stabilizes NFAT5 mRNA and increased the expression of the gluconeogenesis-related genes GLUT1 and PGK1, resulting in enhanced aerobic glycolysis, proliferation, and tumor metastasis of intrahepatic cholangiocarcinoma [41].