The H1 haplotype consists an increased risk for a diverse group of NDs, including tauopathies such as Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration, APOE ɛ4-negative Alzheimer’s disease (AD), Frontotemporal Dementia [8–14], synucleinopathies like Parkinson’s disease (PD) [15, 16] and Dementia with Lewy bodies [17], the Multiple System Atrophy and even Essential Tremor (ET) [18] and Amyotrophic Lateral Sclerosis (ALS) [19]. The gene discussed is APOE; the disease is Alzheimer disease.