In patient 2 (from primary FL to relapse FL with a 2-year gap), we focused on comparing the chromatin accessibility differences in Tumor B1 between the primary tumor (FL) and the paired relapse (FL) and identified 62 peaks for the primary tumor and 38 peaks for the relapse tumor (Fig. 5k, and Supplementary Table 23), with oncogenes such as ZNF384, DDX5, SRSF2, CIC, XPO1, PWWP2A, and NCOA2 showing higher accessibility in the primary tumor, while ZFP36L1 was more accessible in the relapse FL. Here, DDX5 is linked to neoplasm.