Several studies have reported an interaction between the PDZ domain of MAST kinases and proteins such as USP1, SNTB2, PTEN, RABV-G, NHE3, and ACE2, which are involved in diverse processes like longevity, neurite outgrowth, and viral infection (4, 51, 52, 53, 54). This evidence concerns the gene ACE2 and viral infectious disease.