However, the revelation of OMdP related to bEVs, as well as the potential exchange of these molecules between bEVs and the brain parenchyma, which is demonstrated in this study and supported by other research (82, 83), prompted us to examine the possible relationships between OMdP and the key AD hallmark proteins that contribute to the proteinopathy of the disorder, including APP, TAU, and PSENs. This evidence concerns the gene APP and Alzheimer disease.