Moreover, bulk RNA sequencing performed on MNs showed that the axonal CMT samples clustered separately from the controls, identifying genes involved in respiratory chain, axon guidance, and the PI3K-Akt signaling pathways among the common differentially expressed ones, further supporting a link among CMT pathogenesis, mitochondria, and cell metabolism (Van Lent et al., 2021). The gene discussed is AKT1; the disease is Charcot-Marie-Tooth disease.