This review aims to synthesise the role and latest progress of AMPs in combating oral biofilms, with a specific focus on their application potential against Cariogenic Biofilms, Periodontal Disease Biofilms, Root Canal Infection Biofilms, Peri-implantitis Biofilms, and Candida-associated biofilms. The gene discussed is ADSL; the disease is Peri-Implantitis.