The GO‐BP (Figure 2F) and KEGG (Figure 2G) enrichment analyses indicated that overexpression of TRIM15 significantly dysregulated lipid and energy metabolism‐related pathways, including the Cellular response to glucose starvation, the Cellular response to fatty acids, the Regulation of glucose metabolic process, the Glucose metabolic process, the Regulation of lipid storage, the Triglyceride mobilization, the Lipid homeostasis, the Lipid and atherosclerosis, the IL‐17 signaling pathway, the Sphingolipid signaling pathway, the Citrate cycle (TCA cycle), and the Glycolysis/Gluconeogenesis. This evidence concerns the gene TRIM15 and atherosclerosis.