Interestingly, previous studies have shown that FAD‐dependent oxidoreductase domain‐containing protein 1 (FOXRED1), a key factor regulating mitochondrial structure, is closely associated with energy conversion within mitochondria.[28] Additionally, FOXRED1 is involved in regulating colorectal cancer progression as a tumor suppressor gene,[29] but its biological function in EAC is unknown. This evidence concerns the gene FOXRED1 and colorectal cancer.