Interestingly, specific knockdown of TRIM28 in adipocytes leads to the development of obesity, a process involving alterations in lipolysis and TG metabolism.[19] It is clear that the TRIM family is involved in the progression of many obesity‐associated diseases by dysregulating lipid metabolism, but the biological function of the TRIM family in obesity‐induced EAC is unknown. This evidence concerns the gene TRAT1 and Obesity.