Mitochondria are the energy metabolism centers of the cell and are closely related to lipid and glucose metabolism.[27] Combining GO‐BP and KEGG enrichment analyses from the RNA‐seq results of HFD transplantation tumors (Figure 1F,G), TRIM15 (Figure 2F,G), and YY2 (Figure 4B,C) in EAC cells, we found that lipid metabolism and energy metabolism are important processes in the progression of obesity‐associated EAC. The gene discussed is TRIM15; the disease is obesity due to melanocortin 4 receptor deficiency.