Meanwhile, previous studies have shown that TNF‐α induces up‐regulation of TRIM15 expression in breast cancer cells through activation of the NF‐κB pathway.[12] Similarly, the KEGG enrichment analyses of the RNA‐seq data of the HFD and the ND groups’ xenografts showed that the NF‐κB pathway was significantly dysregulated (Figure 1G). The gene discussed is TRIM15; the disease is breast cancer.