Previous studies have clearly demonstrated that inflammatory factors promote the transcriptional upregulation of TRIM15 via the NF‐κB signaling pathway.[12] As members of the serine protease inhibitor family, SERPINB4[49] and SERPINB3[50] primarily function as proto‐oncogenes to drive tumor cell proliferation; however, their association with inflammatory factors remains unclear. Here, SERPINB3 is linked to neoplasm.