Additional links were observed with Chrnb4 in cluster 3 and Cldn17 in cluster 4, both implicated in frontotemporal dementia (FTD), Nefh in cluster 5, associated with ALS, and Vdac2 in cluster 6, associated with Alzheimer’s disease (fig. This evidence concerns the gene VDAC2 and early-onset autosomal dominant Alzheimer disease.