Given the above correlations between CHCHD2 and SNCA gene expression in SNc DA neurons and the distribution of CHCHD2 and CHCHD10 in α-synuclein aggregates in PD cases, we next examined whether α-synuclein accumulates and aggregates in the CHCHD2 T61I mutant mice. The gene discussed is CHCHD2; the disease is Parkinson disease.