Additional links were observed with Chrnb4 in cluster 3 and Cldn17 in cluster 4, both implicated in frontotemporal dementia (FTD), Nefh in cluster 5, associated with ALS, and Vdac2 in cluster 6, associated with Alzheimer’s disease (fig. The gene discussed is CHRNB4; the disease is early-onset autosomal dominant Alzheimer disease.