Moreover, the increase in GABA and glutamate in the brain tissue and TNF in serum are inversely correlated with the decrease in the number of hidden marbles in the MBT, the reduction in the time mice spent in the open arms of the EPMT and the decrease latency in aversive shock evoked test (ASET1) (Fig 9B), sustaining the association of serum TNF concentrations and neurotransmitter changes in the brain tissue with loss of innate compulsive behavior, anxiety and consolidation aversive memory. Here, TNF is linked to Anxiety.