On the other hand, Ki-67, a cell proliferation-associated nuclear antigen, exhibited expression levels that correlated strongly with tumor differentiation, invasive/metastatic potential, and prognosis, making the Ki-67 Labeling Index (Ki-67 LI) a potentially key biomarker for assessing HCC aggressiveness and both recurrence and metastasis risks. This evidence concerns the gene MKI67 and neoplasm.