At the gd 20, there were significant hyperglycemia, altered glucose tolerance, increased total cholesterol, triglycerides, transaminases, liver MDA, SOD, CAT and GSH, reabsorptions sites, post-implantation losses and death fetuses, reduced 17-β-estradiol and numbers of pancreatic cells, corpora luteum, implantation sites and live fetuses in non-treated diabetic mothers, associated with reduced weight and placental and caudal malformations in offsprings. This evidence concerns the gene SOD1 and Hyperglycemia.