KISS1 and type 1 diabetes mellitus: In T1DM, insulin deficiency through the KNDy (kisspeptin, neurokinin B, dynorphin) neural network induces a gonadotropin deficiency (central hypogonadism) and anovulation (infertility), while hyperglycemia accelerates ovarian apoptosis, leading to a reduction in quantity and quality of gametes [6–7].