Although the involvement of GIF/MT-3 and Trx in regulating this disorder has not been elucidated, Trx-mediated reduction of apo-GIF/MT-3 may lead to the reduction of unknown proteins that might suppress the onset of Alzheimer’s disease because of the high antioxidant capabilities of apo-MT persulfides. The gene discussed is TXN; the disease is early-onset autosomal dominant Alzheimer disease.