PRKDC and cancer: In contrast to HR, NHEJ repairs DSBs without the need for a template, often resulting in changes to the DNA sequence.56 NEHJ is responsible for repairing the majority of DSBs caused by ionizing radiation in cancer cells.56 Therefore, alteration of the NHEJ has become a target for anti-tumor therapy.57 Nedisertib has shown to be an effective inhibitor of DNA-PK resulting in suppression of NHEJ.