IL1B and diabetes mellitus: Finally, at the cardiometabolic interface, Western diet, hyperlipidemia, and diabetes drive TI in myeloid cells and exacerbate vascular inflammation; interventions such as statins, IL-1 blockade, and metabolic ‘de-training’ approaches could reduce autoimmune flares in patients with comorbid cardiovascular disease (Riksen et al., 2023; Tercan et al., 2021).