Among the triggers for MS, histone modifications such as deacetylation of oligodendrocyte in MS-associated cells (He et al., 2018) as well as histone citrullination in arginine of H3K9me3 preventing secretion of IL-8 and TNF (Fuhrmann and Thompson, 2016) have been hypothesized to lead to chronic MS lesions. This evidence concerns the gene TNF and myeloid sarcoma.