Given prior epidemiological and mechanistic evidence linking obesity to a worse breast cancer prognosis in postmenopausal women, this study aimed to clarify whether PPARγ expression and adipose tissue proliferative activity, as measured by 18F‐FLT PET‐CT SUV metrics, could help explain this association across tumor subtypes and menopausal states. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.