Subsequently, emerging immune checkpoints such as T cell immunoglobulin domain and mucin domain-3 (TIM-3) and T cell immune receptor with Ig and ITIM domains (TIGIT) have also been shown to be highly expressed in ICC and closely associated with the exhaustion of lymphotoxic immune cells (CD8 + T cells and NK cells) in the TME [32]. The gene discussed is HAVCR2; the disease is intrahepatic cholangiocarcinoma.