MAPT and Alzheimer disease: 2018). The Wnt signaling pathway plays a vital role in controlling cell proliferation and maintaining neuronal balance. Dysregulation of this pathway exacerbates tumor metabolism and concurrently promotes AD features, such as tau hyperphosphorylation and cognitive decline (Pate et al. 2014; Mo et al. 2019; Kostes and Brafman 2023). Loss‐of‐function of canonical Wnt signaling not only induces AD‐like neuropathological changes in wild‐type mice but also accelerates pathological progression of AD mouse models (Tapia‐Rojas and Inestrosa 2018).