HIF1A and central nervous system cancer: Thus, ectopic HIF‐1α expression may subject IDHmut cells to pseudohypoxia, a process that increases the NADH/NAD+ ratio, and may constitute the basis of hypersensitivity to NAD+ deprivation that has been observed in a glioma‐related context.[34] Although previous studies indicated that IDHmut was associated with a higher level of hypoxic response in LGG patients,[35] our study did not observe synergistic effects with IDHmut on HIF‐1α stabilization under hypoxic conditions.