In the current investigation, a significant downregulation of miR-142-5p in HCC tissues and cell lines was observed, findings that resonate with prior reports concerning HBV-related HCC.13 Nevertheless, there remains a dearth of research addressing the regulatory interplay between CKMT2-AS1 and miR-142-5p in the context of HCC progression. This evidence concerns the gene CKMT2 and hepatocellular carcinoma.