Total retinal thickness was comparable for the amyloidosis models (transgenic [tg] and non-transgenic [ntg] APP/PS1 = 209.3 μm and 210.7 μm, and tg and ntg 5xFAD = 212.1 μm and 211.2 μm), but, on average, approximately 17% thicker for the tg and ntg PS19 mice (256.4 μm and 236.8 μm). Here, PSEN1 is linked to amyloidosis.