Several groups investigated the 3xTg mouse models of AD with OCT, a transgenic model that combines amyloid (Swedish APP mutation) and tau pathology (MAPT P301L mutation)19 and reported thinner total retina and all sublayers except the ONL,11 the total retina, and most inner layers (RNFL, IPL, and ONL)23 or thinner RNFL.25 Here, APP is linked to Alzheimer disease.