For example, three dark region‐associated insertions and a retrotransposon insertion were detected near or overlapping Alzheimer's disease‐associated SNPs within ATP binding cassette subfamily A member 7 (ABCA7) (Figure S5E), which encodes an ABC transporter that regulates lipid metabolism,76, 77 amyloid processing, and clearance.78, 79, 80. The gene discussed is ABCA7; the disease is early-onset autosomal dominant Alzheimer disease.