EGR1 has also been reported to be associated with metabolic disorders such as metabolic dysfunctions, insulin resistance and others (54,55), which supports the association between metabolic abnormalities and EGR1. As a transcriptional regulator, EGR1 plays a key role in the regulation of macrophage inflammatory response and it may be hypothesized that metabolic abnormalities could promote inflammation by regulating the expression of EGR1. The gene discussed is EGR1; the disease is Other metabolic disease.