EGR1 and metabolic disease: EGR1 has also been reported to be associated with metabolic disorders such as metabolic dysfunctions, insulin resistance and others (54,55), which supports the association between metabolic abnormalities and EGR1. As a transcriptional regulator, EGR1 plays a key role in the regulation of macrophage inflammatory response and it may be hypothesized that metabolic abnormalities could promote inflammation by regulating the expression of EGR1.