HTT and juvenile Huntington disease: Guo et al. utilized a similar fluorescence-guidedOPTIR setup to determine the secondary structural composition of plaquesin a live yeast cell model of Huntington’s disease. Instead of using fluorescent antibodies, theytagged huntingtin (htt) variants with green fluorescent protein (GFP).However, they also demonstrated the label-free identification of proteinaggregates.