There were no studies that exosomes let‐7g‐5p, let‐7f‐5p and miR‐148a‐3p targeted the Calm/MLCK/p‐MLC2 and Rhoa/ROCK1/p‐MLC2 signal pathway to induce myocardial hypertrophy. This evidence concerns the gene MYLK3 and cardiac hypertrophy.