GSDMD and metabolic dysfunction-associated steatotic liver disease: Additionally, TNFRSF1A upregulation has been associated with caspase-8- and gasdermin D (GSDMD)-dependent PANoptosis in the seasonal atrophy of scented glands in male muskrats [57], and TNFRSF1A overexpression correlates with poor prognosis across multiple cancer types and participates in PANoptosis in nonalcoholic fatty liver disease (NAFLD) [58].