FFAs also activate inflammatory pathways, including NF-κB and JNK, and further activate protein kinase c beta II (PKC-βII) and protein kinase c delta (PKC-δ) in human muscle, which disrupts insulin signaling by impairing IRS function, further propagating hyperglycemia and metabolic dysfunction (48, 49). The gene discussed is PRKCD; the disease is Hyperglycemia.