Parallel nutrient cues (acute hyperglycemia; TRL remnants) activate PKC—especially PKC-β—driving p47^phox translocation and NOX2/NOX4 activation; tetrahydrobiopterin depletion uncouples eNOS, and xanthine oxidase adds to ROS supply—together producing a convergent, multi-organ burst that typically peaks at 1–3 h (84–87). Here, PRRT2 is linked to Hyperglycemia.