In a study conducted by Yang et al. (27), administration of Glycyrrhiza glabra (0.3 g/kg) to six-week-old female Sprague Dawley rats with letrozole-induced PCOS for 2 weeks resulted in increased serum FSH levels, decreased LH: FSH ratio, and significant improvements in ovarian morphological parameters. This evidence concerns the gene BRD2 and polycystic ovary syndrome.