Overexpression of N-acetyltransferase 10 (NAT10) was found to enhance perineural invasion (PNI) in PC by stabilizing ITGB5 via N4-acetylcytidine modification, subsequently activating the ITGB5-pFAK-pSrc pathway to promote PNI (53). This evidence concerns the gene ITGB5 and pachyonychia congenita.