In cutaneous squamous cell carcinoma, TOP2A expression is positively correlated with ferroptosis sensitivity (28).In hepatocellular carcinoma, the small molecule Phillyrin can specifically inhibit TOP2A, block the JAK2/STAT3 signaling axis, and downregulate GPX4 expression, thereby enhancing ferroptosis (29).Additionally, bioinformatics analyses have identified TOP2A as a ferroptosis-resistance regulatory hub (30).However, these studies only focus on the single pathway of ferroptosis and do not involve EMT. Here, JAK2 is linked to hepatocellular carcinoma.