MCOLN1 and cancer: For instance, p53 activation upregulates miR-34a, which inhibits EMT by targeting Zeb1 (71).MCOLN1/TRPML1-induced autophagy inhibition suppresses cancer metastasis by activating the ROS-mediated TP53/p53 pathway (79).These findings provide a theoretical basis for TP53 acting as a hub in the crosstalk between ferroptosis and EMT.