EMT, a core process in ovarian cancer invasion and metastasis, is activated by ECM remodeling and adhesion molecule rearrangement, contributing to cisplatin resistance (66–68).In this study, TOP2A knockdown significantly reduced the invasive capacity of cisplatin-resistant cells, accompanied by characteristic changes in EMT markers: increased E-cad protein expression and decreased expression of N-cad, vimentin, and Snail. The gene discussed is CDH1; the disease is ovarian cancer.