These results indicate that TOP2A knockdown can enhance the sensitivity of OC to cisplatin, whereas TP53 knockdown reduces such sensitivity.Furthermore, through WB analysis of tumor tissues, we confirmed conclusions consistent with in vitro experiments: TOP2A silencing can induce ferroptosis by regulating the expression of TP53/GPX4/SLC7A11, thereby inhibiting the EMT process (Figure 9D). This evidence concerns the gene GPX4 and neoplasm.