TOP2A and ovarian carcinoma: Furthermore, compared with the TOP2A-silenced group, TP53 silencing reversed the changes in the expression of EMT-related proteins induced by TOP2A silencing.Transwell invasion assays and scratch wound healing assays further confirmed that TP53 knockdown not only significantly enhanced the invasive and migratory capacities of cisplatin-resistant ovarian cancer cells but also reversed the inhibition of the EMT process induced by TOP2A knockdown (Figures 8C, D).