First, it verified that TOP2A is highly expressed in ovarian cancer tissues and cisplatin-resistant OC cell lines, and this high expression is associated with poor prognosis in patients.Second, via RNA sequencing(RNA-seq) and mechanistic validation, this study is the first to identify the “TOP2A/TP53/GPX4/SLC7A11” regulatory axis, defining its role in coupling ferroptosis induction with (EMT inhibition. Here, GPX4 is linked to ovarian cancer.