ALPK1 and retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome: According to published studies, single nucleotide polymorphisms (SNPs) or deletion mutations in the ALPK1 gene are genetically linked to the pathogenesis of multiple disorders (16), including Recurrent Periodic Fever (17), ROSAH syndrome, Chronic Kidney Disease (18), Myocardial Infarction, Ischemic Stroke, Spiradenoma, and Adenocarcinoma (19).