CD4 and chronic kidney disease: When evaluation was performed at 1 month after 3rd dose, lower proportion of polyfunctional CD8+ T cells was revealed in CKD, while the proportion of double CD4+ T cells that were positive for CD4, IFNγ and IL-2, as well as triple CD4+ T cells that were positive for CD4, IFNγ, IL-2 and TNF-α, were higher in KTR compared with healthy controls (37).