CD4 and chronic kidney disease: • Anti-S IgG at 4 months after 2nd dose- KT < HD < CG• Anti-S IgG at 1 month after 3rd dose- ↑ more in KT than in HD• Neutralizing Ab after 3rd dose- KT < HD and CG• T-cell response after 2nd dose- CKD < CG• T-cell response and humoral response after 2nd dose- T-cell response: 75% KT- Humoral response: 49% KT• Triple positive CD4+ polyfunctional T cells after 2nd dose- ↑ more in KT than HD• Double and triple positive CD4+ T cells after 3rd dose- ↑ more in KT than HD and CG• CD4+ and CD8+ Memory T cell response after 3rd dose- ↑ in all groups