• Anti-S1/S2 IgG 3 months after vaccination:- (+) in 79% dialysis, 42% KT and 100% CG• Anti-S1/S2 IgG after infection:- (+) in 94% dialysis, 94% KT and 100% CG• Predictors of non-response:- Old age, diabetes, history of cancer, low lymphocyte count, low Vitamin D• Factors associated with lower level of IgG in dialysis- Dialysis modality, high serum ferritin levels• Factors associated with lower level of IgG in KT- Hypertension, higher calcineurin, mTOR inhibitor drugs. The gene discussed is MTOR; the disease is Hypertension.