Additionally, the presence of antibodies against glutamate receptor subunits, notably GluRε2 (NR2B), found in the CSF and serum of certain RP-LE patients, implicates autoimmunity targeting neuronal surface antigens, potentially disrupting synaptic transmission and contributing to excitotoxicity (3, 15, 18). Here, GRIN2B is linked to Autoimmunity.