FTH1 and pancreatic ductal adenocarcinoma: In pancreatic ductal adenocarcinoma (PDAC), circTRIP12 (cTRIP12) drives ferroptosis resistance by binding O-GlcNAc transferase (OGT), elevating O-GlcNAcylation to stabilize ferritin heavy chain (FTH) and PD-L1, thereby suppressing ICD and promoting immune evasion (72).