Similarly, Mn2+-enriched shikonin-loaded nanoparticles induce necroptosis in head and neck squamous cell carcinoma (HNSCC), disrupting mismatch repair to activate cGAS-STING-dependent IFN responses and enhance PD-1 blockade efficacy by promoting DC maturation and cytotoxic T cell infiltration (136–140). The gene discussed is IFNA1; the disease is head and neck squamous cell carcinoma.