From seven candidate NECSO regulators previously implicated in sodium homeostasis (NC1, CLT, DHPs, SLC12A2, SLC8A1, TRPM4, SLC9A1), intersection analysis identified two NECSO-associated DEGs - TRPM4 and SLC9A1 - showing consistent tumor-specific upregulation (Figure 1D). This evidence concerns the gene SLC12A2 and neoplasm.