PRTN3 and rheumatoid arthritis: Our network-based machine learning strategy differentiated ACPA– RA patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.92; ACPA+ RA patients from controls with an AUC of 0.93; and RA patients (combining ACPA– and ACPA+ RA) from controls with an AUC of 0.93 (Table 2).